Effect of Multiple Medicines on Dementia Initial Treatment: Experience and Thinking

American Journal of Alzheimer's Disease &Other Dementias®, Volume 36, Issue , January-December 2021. Little is known about multiple medicines and initial therapy among people with dementia. To examine the effect of multiple medicines on the initiation of anti-dementia therapy in patients diagnosed with cognitive impairment (CI), a retrospective study with 2742 CI patients was conducted based on the outpatients’ medical records. The dementias receiving 1–2 drugs were more likely to be prescr...
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Quantitative MRI Differences Between Early versus Late Onset Alzheimer’s Disease

American Journal of Alzheimer's Disease &Other Dementias®, Volume 36, Issue , January-December 2021. Investigators report greater parietal tau deposition and alternate frontoparietal network involvement in early onset Alzheimer’s Disease (EOAD) with onset <65 years as compared with typical late onset AD (LOAD). To determine whether clinical brain MRI volumes reflect these differences in EOAD compared with LOAD. This study investigated the clinical MRI scans of 45 persons with Clinically ...
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Exploring Effects of Aerobic Exercise and Mindfulness Training on Cognitive Function in Older Adults at Risk of Dementia: A Feasibility, Proof-of-Concept Study

American Journal of Alzheimer's Disease &Other Dementias®, Volume 36, Issue , January-December 2021. Objectives: This study sought to explore feasibility, acceptability, and preliminary effects of aerobic training (AT), mindfulness training (MT), or both (MT + AT) on cognitive function in older individuals at risk of dementia. Method: Participants were randomized to AT, MT, both, or usual care (UC). Z-scores of attention, verbal fluency, and episodic memory for non-demented adults (ZAVEN) w...
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Identification of Hub Genes Related to Alzheimer’s Disease and Major Depressive Disorder

American Journal of Alzheimer's Disease &Other Dementias®, Volume 36, Issue , January-December 2021. BackgroundAlthough many studies reported a close relationship between depression and Alzheimer’s disease (AD), the underlying pathophysiological mechanism remains unclear. The present study aimed to investigate the mechanism of AD and major depressive disorder (MDD). Method: The datasets were downloaded from the Gene Expression Omnibus. After screening differentially expressed genes (DEGs), ...
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