Anxiety and Depression Are Not Related to Increasing Levels of Burden and Stress in Caregivers of Patients With Alzheimer’s Disease

American Journal of Alzheimer's Disease &Other Dementias®, Volume 35, Issue , January-December 2020. Sixty-nine dyads of patients with Alzheimer’s disease and primary caregivers have been followed up for 1 year to evaluate cognitive (Mini-Mental State Examination), functional (Instrumental Activities of Daily Living), and behavioral (Neuropsychiatric Inventory) decline of patient in relation to burden (Caregiver Burden Inventory), stress (Relative Stress Scale), anxiety (State-Trait Anxiety...
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Disclosure of Amyloid Status for Risk of Alzheimer Disease to Cognitively Normal Research Participants With Subjective Cognitive Decline: A Longitudinal Study

American Journal of Alzheimer's Disease &Other Dementias®, Volume 35, Issue , January-December 2020. This study aimed to investigate the long-term impacts of disclosing amyloid status for a risk of Alzheimer disease (AD) to cognitively normal research participants with subjective cognitive decline (SCD), which represents an initial manifestation of AD. Forty-two participants were classified as the amyloid-positive (n = 10) or amyloid-negative (n = 32) groups. We assessed symptoms of anxiety...
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Determining Middle-Aged and Older Adults’ Health Beliefs to Change Lifestyle and Health Behavior for Dementia Risk Reduction

American Journal of Alzheimer's Disease &Other Dementias®, Volume 35, Issue , January-December 2020. Background:Global population is getting older and the prevalence of dementia continuously increases. Understanding the related health beliefs is bound to enable lifestyle-based interventions that maximize public engagement in dementia risk reduction behaviors. The aim of this study was to determine health beliefs on dementia prevention behaviors and lifestyle changes and to determine the fac...
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Reduction of Amyloid in the Brain and Retina After Treatment With IVIG for Mild Cognitive Impairment

American Journal of Alzheimer's Disease &Other Dementias®, Volume 35, Issue , January-December 2020. Objective:To assess whether intravenous immunoglobulin (IVIG) in subjects with mild cognitive impairment (MCI) results in a reduction in amyloid in the central nervous system (CNS).Methods:Five subjects with MCI underwent baseline Florbetapir positron emission tomography and retinal autofluorescent imaging. All were administered IVIG (Octagam 10%) at 0.4 g/kg every 14 days for a total of 5 i...
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Intermittent Hypoxia Training for Treating Mild Cognitive Impairment: A Pilot Study

American Journal of Alzheimer's Disease &Other Dementias®, Volume 35, Issue , January-December 2020. Although intermittent hypoxia training (IHT) has proven effective against various clinical disorders, its impact on mild cognitive impairment (MCI) is unknown. This pilot study examined IHT’s safety and therapeutic efficacy in elderly patients with amnestic MCI (aMCI). Seven patients with aMCI (age 69 ± 3 years) alternately breathed 10% O2 and room-air, each 5 minutes, for 8 cycles/session, ...
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