Study of the Risk and Preventive Factors for Progress of Mild Cognitive Impairment to Dementia

American Journal of Alzheimer’s Disease &Other Dementiasr, Volume 35, Issue , January-December 2020.
Objective:To evaluate the risk factors for progress of mild cognitive impairment to dementia.Methods:This study was based on the epidemiological survey in 2011 (No. PKJ2010-Y26) and contained 441 MCI individuals. Cognitive function was measured by the Mini-Mental Status Examination, clinical dementia rating, and montreal cognitive assessment. The association between demographic characteristics and MCI outcomes were evaluated using single-and multifactor ordered logistic regression analysis models.Results:Of the 441 MCI, 77 progressed to dementia (MCIp: 17.5%, 95% CI: 14.4%-21.6%), 356 remained stable (MCIs: 80.7%, 95% CI: 77.0%-88.4%), and 8 reverted to normal cognition (MCIr: 1.8%, 95% CI: 0.6%-3.0%) at follow-up in 2017. Univariate ordinal regression analysis showed that diabetes (P = .052), marriage (P = .028), worker (P = .069), and manager (P = .075) may be the risk factor for the status of MCI. Multiple ordinal regression results showed that diabetes (P = .049) and marriage (P = .04) significantly affected the cognitive function changes in the MCI patients.Conclusion:Nondiabetics and being married may prevent the progression from MCI to dementia.Study of the Risk and Preventive Factors for Progress of Mild Cognitive Impairment to DementiaStudy of the Risk and Preventive Factors for Progress of Mild Cognitive Impairment to DementiaAlzheimers{$excerpt:n}