New-Onset Alzheimer’s Disease and Normal Subjects 100% Separated Statistically by P300 and ICA

American Journal of Alzheimer's Disease &Other Dementiasr, Volume 35, Issue , January-December 2020. Previously, we described how patients with new-onset Alzheimer’s disease were differentiated from healthy, normal subjects to 100% accuracy, based on the amplitudes of the nonrhythmic back-projected independent components of the P300 peak at the electroencephalogram electrodes and their latency in the response to an oddball, auditory evoked potential paradigm. A neural network and a voting s...
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The Swinging Self: The Costs of Shifting Between Self-Images in Alzheimer’s Disease

American Journal of Alzheimer's Disease &Other Dementiasr, Volume 35, Issue , January-December 2020. Background:We investigated the ability of patients with Alzheimer’s disease (AD) to shift between different self-images.Methods:We developed an original task (shifting-self task) in which we invited 28 patients with AD and 30 control participants to generate “who am I” statements that describe 2 alternative self-images (ie, physical-self vs psychological-self). In a control task, participant...
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Machine-Learning Algorithms Based on Screening Tests for Mild Cognitive Impairment

American Journal of Alzheimer's Disease &Other Dementiasr, Volume 35, Issue , January-December 2020. Background:The mobile screening test system for mild cognitive impairment (mSTS-MCI) was developed and validated to address the low sensitivity and specificity of the Montreal Cognitive Assessment (MoCA) widely used clinically.Objective:This study was to evaluate the efficacy machine learning algorithms based on the mSTS-MCI and Korean version of MoCA.Method:In total, 103 healthy individuals...
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Longitudinal Sensitivity of Alzheimer’s Disease Severity Staging

American Journal of Alzheimer's Disease &Other Dementiasr, Volume 35, Issue , January-December 2020. Understanding Alzheimer’s disease (AD) dynamics is essential in diagnosis and measuring progression for clinical decision-making; however, clinical instruments are imperfect at classifying true disease stages. This research evaluates sensitivity and determinants of AD stage changes longitudinally using current classifications of “mild,” “moderate,” and “severe” AD, using Mini-Mental State Ex...
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Study of the Risk and Preventive Factors for Progress of Mild Cognitive Impairment to Dementia

American Journal of Alzheimer's Disease &Other Dementiasr, Volume 35, Issue , January-December 2020. Objective:To evaluate the risk factors for progress of mild cognitive impairment to dementia.Methods:This study was based on the epidemiological survey in 2011 (No. PKJ2010-Y26) and contained 441 MCI individuals. Cognitive function was measured by the Mini-Mental Status Examination, clinical dementia rating, and montreal cognitive assessment. The association between demographic characteristi...
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Neuroprotective Properties and Therapeutic Potential of Bone Marrow–Derived Microglia in Alzheimer’s Disease

American Journal of Alzheimer's Disease &Other Dementiasr, Volume 35, Issue , January-December 2020. Alzheimer’s disease (AD) is the most common form of dementia, which is characterized by a progressive cognitive decline and senile plaques formed by amyloid β (Aβ). Microglia are the immune cells of the central nervous system (CNS). Studies have proposed 2 types of microglia, namely, the resident microglia and bone marrow–derived microglia (BMDM). Recent studies suggested that BMDM, not the ...
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