Preliminary Validation of the Triana Test: A New Story Recall Test Based on Emotional Material

American Journal of Alzheimer's Disease &Other Dementiasr, Volume 36, Issue , January-December 2021. Objective:To first validate the diagnostic accuracy of the “Triana Test,” a new story recall test based on emotional material.Method:A phase I study of validation. We included 55 patients with amnestic Mild Cognitive Impairment and 69 healthy controls, diagnosed according to the “Memory Associative Test of the district of Seine-Saint-Denis” (TMA-93), and matched by age, gender, and education...
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Oral Amylin Treatment Reduces the Pathological Cascade of Alzheimer’s Disease in a Mouse Model

American Journal of Alzheimer's Disease &Other Dementiasr, Volume 36, Issue , January-December 2021. Intraperitoneal injection of amylin or its analog reduces Alzheimer’s disease (AD) pathology in the brains. However, self-injecting amylin analogs is difficult for patients due to cognitive deficits. This work aims to study the effects of amylin on the brain could be achieved by oral delivery as some study reported that amylin receptor may be present in the gastrointestinal tract. A 6-week c...
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MiR-130a-3p Has Protective Effects in Alzheimer’s Disease via Targeting DAPK1

American Journal of Alzheimer's Disease &Other Dementiasr, Volume 36, Issue , January-December 2021. The present study investigated the role and potential mechanisms of miR-130a-3p in AD. SH-SY5Y cells were treated with Aβ 1-42 to construct AD cell models. APP/PS1 mice were used for the animal experiments.  MiR-130a-3p was downregulated in Aβ-induced SH-SY5Y cells. Overexpression of miR-130a-3p attenuates Aβ induced SH-SY5Y cell apoptosis. Low miR-130a-3p expression was detected in the hipp...
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Analysis of Serum miRNAs in Alzheimer’s Disease

American Journal of Alzheimer's Disease &Other Dementiasr, Volume 36, Issue , January-December 2021. This paper was aimed to analyze the microRNA (miRNA) signatures in Alzheimer disease (AD) and find the significant expressions of miRNAs, their target genes, the functional enrichment analysis of the confirmed genes, and potential drug treatment. The miRNA expression information of the gene expression profile data was downloaded from the Gene Expression Omnibus database. The total data sampl...
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Clinical Markers May Identify Patients at Risk for Early Parkinson’s Disease Dementia: A Prospective Study

American Journal of Alzheimer's Disease &Other Dementiasr, Volume 36, Issue , January-December 2021. Background:The study aims at identifying features predictive of early onset of dementia in Parkinson’s disease (PD).Methods:103 non-demented PD patients were evaluated on various scales at baseline and 89 patients at 3-year follow-up.Results:By the end of the study 43.8% of patients developed dementia. The development of dementia was linked to the baseline Mini Mental State Examination score...
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Incidence of Mild Cognitive Impairment, Conversion to Probable Dementia, and Mortality

American Journal of Alzheimer's Disease &Other Dementiasr, Volume 36, Issue , January-December 2021. Background:Few studies have jointly estimated incidence of MCI, conversion to probable dementia, and mortality in a nationally representatie sample.Methods:We used data from six waves of the National Health and Aging Trends Study (2011-2016). Multivariable-adjusted multi-state survival models (MSMs) were used to model incidence upon accounting for misclassification.Results:A total of 6,078 e...
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