Quantitative MRI Differences Between Early versus Late Onset Alzheimer’s Disease

American Journal of Alzheimer's Disease &Other Dementias®, Volume 36, Issue , January-December 2021. Investigators report greater parietal tau deposition and alternate frontoparietal network involvement in early onset Alzheimer’s Disease (EOAD) with onset <65 years as compared with typical late onset AD (LOAD). To determine whether clinical brain MRI volumes reflect these differences in EOAD compared with LOAD. This study investigated the clinical MRI scans of 45 persons with Clinically ...
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Exploring Effects of Aerobic Exercise and Mindfulness Training on Cognitive Function in Older Adults at Risk of Dementia: A Feasibility, Proof-of-Concept Study

American Journal of Alzheimer's Disease &Other Dementias®, Volume 36, Issue , January-December 2021. Objectives: This study sought to explore feasibility, acceptability, and preliminary effects of aerobic training (AT), mindfulness training (MT), or both (MT + AT) on cognitive function in older individuals at risk of dementia. Method: Participants were randomized to AT, MT, both, or usual care (UC). Z-scores of attention, verbal fluency, and episodic memory for non-demented adults (ZAVEN) w...
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Identification of Hub Genes Related to Alzheimer’s Disease and Major Depressive Disorder

American Journal of Alzheimer's Disease &Other Dementias®, Volume 36, Issue , January-December 2021. BackgroundAlthough many studies reported a close relationship between depression and Alzheimer’s disease (AD), the underlying pathophysiological mechanism remains unclear. The present study aimed to investigate the mechanism of AD and major depressive disorder (MDD). Method: The datasets were downloaded from the Gene Expression Omnibus. After screening differentially expressed genes (DEGs), ...
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Implications of the COVID-19 Pandemic on Adult Day Services and the Families They Serve

American Journal of Alzheimer's Disease &Other Dementias®, Volume 36, Issue , January-December 2021. The COVID-19 pandemic forced adult day services (ADS) to close and abruptly end in-person services to clients. To understand the effect of the pandemic on ADS, a 20-item survey was used to examine services provided, staffing, finances, and plans to reopen. Data came from 22 sites participating in the Adult Day Service Plus a national randomized controlled trial. Of the 22 ADS sites respondin...
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The Impact of Diet Type on Weight Loss in Patients with Alzheimer’s Disease

American Journal of Alzheimer's Disease &Other Dementias®, Volume 36, Issue , January-December 2021. Objectives: To compare differences in weight loss in patients with Alzheimer’s disease on normal, diabetic, or texture-modified diets. Methods: This prospective interventional study examined the data of patients with Alzheimer’s disease who were admitted to a long-term care hospital in Japan from February to April 2013. Dietary elements and weight loss over a 3-month period were examined. Re...
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Trends in Mortality Rates for Alzheimer’s Disease and Other Dementias Over 30 Years in China

American Journal of Alzheimer's Disease &Other Dementias®, Volume 36, Issue , January-December 2021. Objective: This study examines trends in the mortality of Alzheimer’s disease and other dementias in China from 1990 to 2019. Methods: The data were drawn from the Global Burden of Disease Study 2019 (GBD 2019), and an age–period–cohort model was used for analysis. Results: The net drift was .152% (95% confidence interval [CI]: .069%, .235%) per year for men (P < .05) and .024% (95% CI: −...
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