β-Hydroxybutyrate Ameliorates Aβ-Induced Downregulation of TrkA Expression by Inhibiting HDAC1/3 in SH-SY5Y Cells

American Journal of Alzheimer's Disease &Other Dementias®, Ahead of Print. Tyrosine kinase receptor A (TrkA) plays an important role in the protection of cholinergic neurons in Alzheimer’s disease (AD). This study was designed to investigate whether β-hydroxybutyrate (BHB), an endogenous histone deacetylase (HDAC) inhibitor, upregulates the expression of TrkA by affecting histone acetylation in SH-SY5Y cells treated with amyloid β-protein (Aβ). The results showed that BHB ameliorated the re...
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Development of an ICT-Based Dementia Care Mapping Support System and Its Usefulness Assessment

American Journal of Alzheimer's Disease &Other Dementias®, Ahead of Print. Objectives:Dementia Care Mapping (DCM) is an established practice method to implement Person-centred Care in dementia care settings. However, it is not easy to carry out DCM because of its high complexity. The aim of this study is to solve DCM complexity by adopting technology.Methods:Authors developed (1) a new information-communication technology (ICT) based DCM support system based on the investigation of difficul...
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