Observed Physical Function Is Associated With Better Cognition Among Elderly Adults: The Adventist Health Study-2

American Journal of Alzheimer's Disease &Other Dementiasr, Volume 35, Issue , January-December 2020. Lifestyle factors may individually protect against the development of mild cognitive impairment. We investigate the relationships between both self-reported physical activity and measured physical function with cognition in a population of elderly adults, more than half of whom follow vegetarian dietary patterns. Otherwise healthy adults (n = 127, mean age 74.9 ± 7.9 years, 61.3% current veg...
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Stress-Induced Neurodegeneration: The Potential for Coping as Neuroprotective Therapy

American Journal of Alzheimer's Disease &Other Dementiasr, Volume 35, Issue , January-December 2020. Stress responses are essential for survival, but become detrimental to health and cognition with chronic activation. Chronic hypothalamic-pituitary-adrenal axis release of glucocorticoids induces hypothalamic-pituitary-adrenal axis dysfunction and neuronal loss, decreases learning and memory, and modifies glucocorticoid receptor/mineralocorticoid receptor expression. Elderly who report incre...
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An Agenda for Addressing Multimorbidity and Racial and Ethnic Disparities in Alzheimer’s Disease and Related Dementia

American Journal of Alzheimer's Disease &Other Dementiasr, Volume 35, Issue , January-December 2020. Advancements in Alzheimer’s disease and related dementias (ADRD) research on the U.S. population acknowledge the importance of the high burden of ADRD on segments of the population and yet-to-be characterized risks attributable to the burden of multiple chronic diseases (multimorbidity). These realizations suggest successful strategies in caring for people with ADRD and their caregivers will...
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Neuropsychological and Functional Impact of COVID-19 on Mild Cognitive Impairment

American Journal of Alzheimer's Disease &Other Dementiasr, Volume 35, Issue , January-December 2020. We present a case report to showcase that behavioral, cognitive, and functional decline may be associated with COVID-19 stay-home guidance among older adults with pre-existent cognitive impairment. In a functionally independent and physically active older adult with Mild Cognitive Impairment, there was worsening in depression and anxiety symptoms associated with the restrictions of COVID-19....
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A Reliable Tool for Assessing MCI and Dementia: Validation Study of DemTect for Turkish Population

American Journal of Alzheimer's Disease &Other Dementiasr, Volume 35, Issue , January-December 2020. Background and Aim:Mild cognitive impairment (MCI) and dementia prevalence are expected to increase with aging. The DemTect is a very quick and easy tool to administer and recognize the early stages of dementia and MCI. In this study we aimed to evaluate the reliability and validity of a Turkish version of the DemTect and define cut off values for different age and educational levels. One of...
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The Dual GLP-1/GIP Receptor Agonist DA4-JC Shows Superior Protective Properties Compared to the GLP-1 Analogue Liraglutide in the APP/PS1 Mouse Model of Alzheimer’s Disease

American Journal of Alzheimer's Disease &Other Dementiasr, Volume 35, Issue , January-December 2020. Alzheimer’s disease (AD) is a neurodegenerative disorder for which there is no cure. Here, we test a dual GLP-1/GIP receptor agonist (DA4-JC) that has a cell penetrating sequence added to enhance blood-brain barrier penetration. We show in a receptor activity study that DA4-JC has balanced activity on both GLP-1 and GIP receptors but not on GLP-2 or Glucagon receptors. A dose-response study ...
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