Circulating MicroRNAs as Diagnostic Biomarkers of Clinical Cognitive Impairment: A Meta-Analysis

American Journal of Alzheimer's Disease &Other Dementiasr, Volume 35, Issue , January-December 2020. Background:Minimally invasive diagnostic biomarkers of neurodegenerative diseases such as Alzheimer’s disease (AD) facilitate patient selection and cognitive progressive decline monitoring. However, the diagnostic value of circulating microRNAs (miRNAs) for early cognitive impairment and progression to dementia is currently under debate. Thus, this study aimed to assess the diagnostic perfor...
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Caregivers’ Dementia Knowledge and Care Approach in Residential Aged Care Facilities in China

American Journal of Alzheimer's Disease &Other Dementiasr, Volume 35, Issue , January-December 2020. Objective:To investigate the dementia knowledge and care approach used by caregivers in residential aged care facilities (RACFs) in China.Method:A cross-sectional survey of 785 caregivers from a random sample of 34 RACFs in China. Caregivers’ knowledge and care approach were assessed using the Chinese version of the Dementia Knowledge Assessment Tool 2 and Advanced Dementia Care Questionnair...
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Internal Lipid Profile and Body Lipid Profile in Relation to Cognition: A Cross-Sectional Study in Southern China

American Journal of Alzheimer's Disease &Other Dementiasr, Volume 35, Issue , January-December 2020. Aim:There are currently no established, clinically relevant, non-invasive markers of cognitive impairment, except for age and APOE genotype.Methods:A cross-sectional study of 1,296 participants from Nanchang, China, has been conducted. We collected data from Mini–Mental State Examination (MMSE) scores, internal lipid profiles and body lipid profiles, age and other factors that may have an ef...
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Low Hippocampal Dentate Gyrus Volume Associated With Hypertension-Related Cognitive Impairment

American Journal of Alzheimer's Disease &Other Dementiasr, Volume 35, Issue , January-December 2020. Hypertension increases the risk of cognitive impairment independent of detectable stroke or cerebral lesions. However, the principal pathophysiological basis of this increase has not been fully elucidated. The present study investigates the relationships among blood pressure, hippocampal subfields volume, and cognitive function in a relatively young non-stroke population. A total of 59 non-s...
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Aphasia in Alzheimer’s Disease and Other Dementias (ADOD): Evidence From Chinese

American Journal of Alzheimer's Disease &Other Dementiasr, Volume 35, Issue , January-December 2020. Speech and language impairments (aphasia) are typical of patients with Alzheimer’s Disease and other dementias (ADOD) and in some pathologies are diagnostic e.g. Primary Progressive Aphasia (PPA). One question concerns the reliability and validity of symptomatology across typologically different languages. A review of aphasia in ADOD across languages suggests a similar pattern of word compre...
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Observed Physical Function Is Associated With Better Cognition Among Elderly Adults: The Adventist Health Study-2

American Journal of Alzheimer's Disease &Other Dementiasr, Volume 35, Issue , January-December 2020. Lifestyle factors may individually protect against the development of mild cognitive impairment. We investigate the relationships between both self-reported physical activity and measured physical function with cognition in a population of elderly adults, more than half of whom follow vegetarian dietary patterns. Otherwise healthy adults (n = 127, mean age 74.9 ± 7.9 years, 61.3% current veg...
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