Clinical Markers May Identify Patients at Risk for Early Parkinson’s Disease Dementia: A Prospective Study

American Journal of Alzheimer’s Disease &Other Dementiasr, Volume 36, Issue , January-December 2021.
Background:The study aims at identifying features predictive of early onset of dementia in Parkinson’s disease (PD).Methods:103 non-demented PD patients were evaluated on various scales at baseline and 89 patients at 3-year follow-up.Results:By the end of the study 43.8% of patients developed dementia. The development of dementia was linked to the baseline Mini Mental State Examination score (Pearson coefficient r = .404, p = 0.013), the presence of autonomic dysfunctions (r = −.621, p < 0.001) and insomnia (r = −.526, p = 0.001). A binary logistic regression analysis showed that the development of dementia was correlated strongly with the presence of autonomic dysfunctions (95% CI 2.60 to 52.83, p < 0.001), and insomnia (95% CI 0.60 to 0.95, p = 0.017).Conclusion:Patients with signs of autonomic dysfunction and insomnia are at higher risk for developing dementia and deserve closer monitoring of cognitive symptoms.Clinical Markers May Identify Patients at Risk for Early Parkinson’s Disease Dementia: A Prospective StudyClinical Markers May Identify Patients at Risk for Early Parkinson’s Disease Dementia: A Prospective StudyAlzheimers{$excerpt:n}