Decreased Levels of Serum IGF-1 and Vitamin D Are Associated With Cognitive Impairment in Patients With Type 2 Diabetes

American Journal of Alzheimer's Disease &Other Dementias®, Ahead of Print. Purpose:To determine the association of serum insulin-like growth factor 1 (IGF-1) and vitamin D levels with cognition status in patients with type 2 diabetes mellitus (T2DM).Methods:A total of 173 patients with T2DM were recruited and divided into mild cognitive impairment (MCI) group (n = 94) and normal cognition (NC) group (n = 79). Levels of IGF-1 and 25(OH)D were measured and compared, and the correlations among...
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Biosignals to Detect the Imbalance of Explicit and Implicit Affect in Dementia: A Pilot Study

American Journal of Alzheimer's Disease &Other Dementias®, Ahead of Print. Background:We assessed implicit and explicit emotion in older patients with dementia using biosignals.Methods:Fifty patients with dementia and 34 healthy individuals watched 3 videos that aimed to elicit various emotional responses. Electroencephalogram and heart rate variability were recorded.Results:Patients with dementia experienced less fun and more fear than controls. The high frequency (HF) from the baseline in...
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Treatment Indications in Clinical Practice and Applied Research on Psychosocial Interventions for People With Dementia

American Journal of Alzheimer's Disease &Other Dementias®, Ahead of Print. A recent review of Cochrane meta-analyses on psychosocial interventions (PIs) concludes that clinical trials fail to confirm PIs effective for all types of dementia at every stage of the disease. This article describes how and to what extent it is necessary to identify treatment indications when researching PIs and employing them in clinical practice. Twelve Cochrane reviews on PIs for people with dementia, selected ...
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Age-Related Effect of Antihypertensive Treatment on Cognitive Performance: Is it Better Preventing Dementia in Older Age?

American Journal of Alzheimer's Disease &Other Dementias®, Ahead of Print. The aim of this study is to investigate the impact of optimal antihypertensive medication on cognitive function. In this 6-month clinical trial, 248 adults were randomly selected by a registry of hypertensive-treated patients (based on a National Hypertension Treatment Program), followed health centers located in Rafsanjan County, Southeast, Iran. Blood pressure was measured 3 times in each appointment pre- and postt...
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Investigation of the Effects of Biochemical Parameters on Alzheimer’s Disease

American Journal of Alzheimer's Disease &Other Dementias®, Ahead of Print. Background:The most common type of dementia is an Alzheimer’s disease which is a major concern in growing chronic diseases in the geriatric society, and its connection with biochemistry has not been sufficiently understood.Objective:This study aims to evaluate the effects of blood biochemistry on Alzheimer’s disease.Method:Eight participants aged 55+ with Alzheimer’s disease were analyzed. A cross-sectional work has ...
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The Effects of Intuitive Movement Reembodiment on the Quality of Life of Older Adults With Dementia: A Pilot Study

American Journal of Alzheimer's Disease &Other Dementias®, Ahead of Print. Background:The creative use of reminiscent music and natural movements were reported to have positive effects on the well-being of older adults with cognitive impairment.Objectives:To explore the effects of the intuitive movement reembodiment (IMR) program on the quality of life (QoL) of older adults with dementia.Methods:Data collected from 22 participants were analyzed: group 1 (mild dementia), group 2 (moderate de...
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