Comparison of Urinary Alzheimer-Associated Neural Thread Protein (AD7c-NTP) Levels Between Patients With Amnestic and Nonamnestic Mild Cognitive Impairment

American Journal of Alzheimer's Disease &Other Dementias®, Ahead of Print. Urinary Alzheimer-associated neural thread protein (AD7c-NTP) is a potential biomarker of Alzheimer disease (AD) or mild cognitive impairment (MCI). It is still unclear whether the urinary levels of AD7c-NTP are different between patients with amnestic MCI (aMCI) and nonamnestic MCI (naMCI). The present study aimed to explore the differences in urinary levels of AD7c-NTP between patients with aMCI and naMCI. Forty-si...
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Experiences of Living With Primary Progressive Aphasia: A Scoping Review of Qualitative Studies

American Journal of Alzheimer's Disease &Other Dementias®, Ahead of Print. Introduction:Understanding the experiences of people who live with primary progressive aphasia (PPA) can inform the development of appropriate speech-language pathology services for this population. This review aimed to summarize the qualitative research on the experience of living with PPA from the perspective of the individuals with the disorder and their families.Methods:A scoping review was conducted.Results:Eigh...
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Horticultural Therapy in Patients With Dementia: A Systematic Review and Meta-Analysis

American Journal of Alzheimer's Disease &Other Dementias®, Ahead of Print. Background:World Health Organization has communicated that dementia as a public health priority in 2012. Behavioral and psychological symptoms of dementia are the main reason results in hospitalization of dementia patients. Horticulture is one of the favorite activity for many peoples to relax their minds.Objectives:To investigate psychological health benefits of horticulture intervention in dementia patients.Methods...
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Factors Affecting Caregivers’ Acceptance of the Use of Wearable Devices by Patients With Dementia: An Extension of the Unified Theory of Acceptance and Use of Technology Model

American Journal of Alzheimer's Disease &Other Dementias®, Ahead of Print. Purpose:This study aims to examine the factors affecting caregivers’ acceptance of the use of wearable devices by patients with dementia by extending the Unified Theory of Acceptance and Use of Technology (UTAUT) model with 2 additional constructs: resistance to change (RC) and technology anxiety (TA).Methods:A structured online questionnaire was developed and distributed to caregivers who have either dealt previousl...
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β-Hydroxybutyrate Ameliorates Aβ-Induced Downregulation of TrkA Expression by Inhibiting HDAC1/3 in SH-SY5Y Cells

American Journal of Alzheimer's Disease &Other Dementias®, Ahead of Print. Tyrosine kinase receptor A (TrkA) plays an important role in the protection of cholinergic neurons in Alzheimer’s disease (AD). This study was designed to investigate whether β-hydroxybutyrate (BHB), an endogenous histone deacetylase (HDAC) inhibitor, upregulates the expression of TrkA by affecting histone acetylation in SH-SY5Y cells treated with amyloid β-protein (Aβ). The results showed that BHB ameliorated the re...
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Development of an ICT-Based Dementia Care Mapping Support System and Its Usefulness Assessment

American Journal of Alzheimer's Disease &Other Dementias®, Ahead of Print. Objectives:Dementia Care Mapping (DCM) is an established practice method to implement Person-centred Care in dementia care settings. However, it is not easy to carry out DCM because of its high complexity. The aim of this study is to solve DCM complexity by adopting technology.Methods:Authors developed (1) a new information-communication technology (ICT) based DCM support system based on the investigation of difficul...
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